I wrote this in response to an email I got from an American flying in for the first time in Toronto and thought I'd repost it here so that it might be of help for other people.
If anyone has anything they'd like to add (from personal experience or otherwise) please feel free to respond.
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Hi, the venue for the party is called The Opera House which is located near downtown Toronto. The airport is on the west side of the city. so you'll need to get from there to closer downtown. There are airport shuttle buses which will take you to a variety of
hotels/locations downtown for around $25 (canadian). A taxi will cost about $40. I think there's also TTC (toronto transit) for much cheaper, and that will involve taking a bus, and then transfering to the subway. That'll be an adventure but much cheaper (Totally safe though, toronto is a very safe city). I found a link to their website:
http://www.city.toronto.on.ca/ttc/s..._to_airport.htm
I recommend you stay at a hotel somewhere during your stay. The Days Inn in Downtown Toronto (30 Carlton St) (Daysinn.com for reservations) (Subway stops right near it (the college/carleton street stop) can be booked for about $100 canadian a night. The Opera House is less than $10 from most downtown hotels. There is also a 24 hour street car which runs down Queen St (one of the bigger streets here) from downtown to right in front of the venue.
Here is a mapquest link to the venue:
http://www.mapquest.com/maps/map.ad...=69&submit.y=12
The Opera House also has a website:
http://www.theoperahousetoronto.com
I also recommend
http://www.toronto.com for looking up stuff.